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ADARO Letro 2.5
  • ADARO Letro 2.5
  • ADARO Letro 2.5
ADARO Letro 2.5

ADARO Letro 2.5

Rs. 299.00

Letrozole is a potent, non-steroidal aromatase inhibitor (AI) that selectively blocks the aromatase enzyme responsible for the peripheral conversion of androgens (androstenedione and testosterone) into estrogens (estrone and estradiol). By suppressing estrogen biosynthesis, Letrozole effectively reduces estrogen-dependent tumor growth in hormone-sensitive cancers and is also widely utilized in reproductive endocrinology for ovulation induction.

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Indications

Ovulation Induction in Women with Anovulatory Infertility (e.g., PCOS)
Controlled Ovarian Hyperstimulation in ART protocols
Clinical & Safety Profile

Contraindications:

● Hypersensitivity to Letrozole or excipients.
● Premenopausal women with intact ovarian function (unless under specialist infertility protocol).
● Pregnancy and lactation (Category X).
● Severe hepatic impairment without specialist supervision.

Potential Drug Interactions:

● May interact with tamoxifen or estrogen-containing therapies, reducing efficacy.
● Concomitant CYP2A6 and CYP2C19 substrates may require dose adjustment.
● Alcohol use may exacerbate CNS-related adverse effects.

Adverse Reactions:

● Common: Hot flashes, fatigue, dizziness, arthralgia, headache, sweating.
● Oncology patients: Osteoporosis, bone fractures, cardiovascular events (long-term use).
● Infertility patients: Multiple pregnancies, ovarian cyst formation, mild ovarian hyperstimulation.
● Other: Nausea, edema, mood changes.
Warnings & Precautions

1. Bone Health: Long-term use may cause bone mineral density reduction; monitor and consider calcium/vitamin D supplementation.
2. Cardiovascular Risk: Use cautiously in patients with history of ischemic heart disease or dyslipidemia.
3. CNS Effects: May cause dizziness or fatigue; caution with driving or operating machinery.
4. Fertility Use: Strict monitoring with ultrasound and hormone testing required during ovulation induction cycles.
5. Pediatric Use: Safety and efficacy not established in children.
Product Storage & Handling

● Store at controlled room temperature (15–30°C).
● Protect from moisture and direct sunlight.
● Keep out of reach of children.
Ethical Considerations

● Prescription-only medicine; not intended for off-label use in bodybuilding or performance enhancement.
● Compliance with FDA, EMA, and ICMR reproductive medicine guidelines.
● Subject to pharmacovigilance and ongoing monitoring in oncology patients.

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